Genetics can play a role in whether a person develops an how a person experiences and copes with chronic pain

Certain genetic variations can affect how the body responds to pain, how sensitive a person is to pain, and how effectively they are able to cope with pain.

For example, some genetic variations have been linked to conditions that can cause chronic pain, such as fibromyalgia and osteoarthritis. Other genetic variations can affect the production and activity of brain chemicals and other signalling
molecules that play a role in pain perception and processing.

Genetic factors can also influence how a person responds to pain medications. Some medications may work better for some people than for others, due in part to genetic variations. How many side-effects and what kind of side-effects you
experience may also be due to your genes. 

However, it's important to note that genetics is just one of many factors that can contribute to chronic pain. Lifestyle factors, environmental factors, and psychological factors can also play a significant role in the experience of chronic pain. A holistic approach that considers all of these factors is often necessary for
effective pain management.


There is no single gene or genetic deviation that has been identified as a direct cause of chronic back pain. Back pain is a complex condition that can be influenced by multiple factors, including genetics, lifestyle, and environmental factors.

However, some studies have suggested that certain genetic variations may be associated with an increased risk of developing back pain. For example, variations in
genes related to the structure and function of the spine, muscles, and
connective tissues have been implicated in some cases of back pain.

Other studies have suggested that genetic variations related to the body's inflammatory response and pain processing pathways may also play a role in the development of chronic back pain.

It's important to note that genetics is just one of many factors that can contribute to chronic back pain. Lifestyle factors, such as poor posture and lack of exercise, can also contribute to back pain. Effective management of chronic
back pain often involves a multidisciplinary approach that considers all of these factors.


Epigenetics is the study of how gene expression can be influenced by factors beyond changes to the DNA sequence itself, such as environmental factors and lifestyle
choices. This means that while a person's genetic makeup cannot be changed, the way genes are expressed can be influenced by external factors.

In the case of back pain, there is growing evidence to suggest that epigenetic changes may play a role in the development and progression of the condition. For example, lifestyle factors such as smoking, diet, and physical activity can all influence the expression of genes that are involved in inflammation, pain processing, and tissue repair.

Improving your outcomes in back pain may involve taking steps to improve your overall health and well-being, which can help to reduce the impact of epigenetic changes that may be contributing to your pain. This might include adopting a
healthy diet, quitting smoking, increasing physical activity levels, and managing stress.

Additionally, some research suggests that mind-body interventions such as mindfulness-based stress reduction and cognitive-behavioral therapy may be able to modify the expression of genes that are involved in pain processing and stress response.
By addressing both physical and psychological factors that may be contributing to your back pain, you may be able to improve your outcomes and reduce the impact of chronic pain on your daily life.